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Still Scared of Injections?


Transdermal delivery is not a new concept to the US. For many years, technologies such as DC Current, Iontophoresis, Electroporation, and Ultrasounds have been providing the benefits of transdermal delivery, however, they all had their own limitations. So that you have a better understanding of how we developed our newest technology, Dermoelectroporation, we thought we would provide you with the limits of the existing technologies first.

Limitations of Existing Technologies

Iontophoresis is an active (electrically driven) method of delivery drugs into the body. It is based on the fact that compounds are composed of both positive and negative charged ions. When these compounds are placed in an appropriate solution, they dissociate into their polar components and assume a positive or negative charge. While in a charged state, each ion can be influenced by an electrical field within the solution. Positive charged ions are attracted to the negative pole and repelled from the positive pole, and vice versa. This electro-repulsion of like charges is the driving force for Iontophoresis.

Limits of Iontophoresis

  • Electrolysis reaction at the electrodes

  • Change in the pH of the ionic drug solution

  • Ineffective for delivering high weight molecules (only drug molecules  less than 10,000 Dalton are deliverable) 

Electroporation is a non-invasive method of delivery drugs into the body. When a high level electrical current is applied to a drug solution, Electroporation drives the drug ions through the skin breaking the stratum corneum.

Limits of Electroporation

  • This high level electrical current causes severe skin damage.

  • Burnings

  • Discomfort

  • Pain

We all have natural water-based channels. Ultrasounds have a vibration feature that creates distance between these channels allowing the ionic drug solution to penetrate and pass through.

Limits of Ultrasounds

  • No electrical current is applied

  • Effects limited to the skins surface

  • Ineffective for delivering high weight molecules

Mattioli Engineering's Solution

Mattioli Engineering removed the limits by combining the advantages of the existing technologies to create the Transderm Ionto System.

The Transderm Ionto System, using Mattioli Engineering's newest technology - Dermoelectroporation, is the only transdermal delivery device FDA cleared as an alternative to injections.

Technology Description

Dermoelectroporation is a patented, proprietary technology from Mattioli Engineering. It utilizes the skins water based "channels" to allow ionic drug solutions to penetrate due to controlled "electroporation-like" continuous reversed polarity electrical pulses. Because of this, Dermoelectroporation is able to control the average pulse value and vary the pulse shape according to the skins specific electrical impedance.

Dermoelectroporation promotes the transdermal delivery of both micro- and macro molecules (more than 800,000Dalton) safely into the body without the need of modifying the ionic drug solution pH, as with traditional iontophoresis. Dermoelectroporation does not require a pH compensation patch, driving gels, or pre-charged ions.

Unlike traditional iontophoresis, Dermoelectroporation does not have an electrolysis reaction at the site of the electrodes. There is no degradation of the molecule being delivered.This means that both positive and negative ions of the drug are delivered into the body - the drug is delivered as a whole.

Benefits of Dermoelectroporation

  • Non-invasive

  • No trauma or bruising from an injection

  • Capability to transdermally deliver both micro- and macro molecules

  • No electrolysis reaction at the site of the electrodes

  • No variation or change in the ionic drug solution pH, ensuring that the patient experiences no discomfort or irritation

  • Both positive and negative ions are transdermally delivered