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Dermoelectroporation - Frequent Asked Questions 
 

Technique FAQs

Q) What's Ultrapeel® Transderm® Meso System?

A) Ultrapeel® Transderm® Meso System is the newest needles free alternative to injection equipment. It is the only machine FDA cleared to be considered alternative to injections and it is possible to deliver molecules up to 800.000 dalton with no side effects and contraindications. The system is currently used for No needles mesotherapy, cellulite, skin texture enhancement treatments, Hyaluronic acid, ammminoacids, vitamins, Pre-Laser Applications, Collagen, elastine etc.

 

Q) What technology does Ultrapeel® Transderm® Meso System use?

A) Ultrapeel® Transderm® Meso System uses Dermoelectroporation® Technology.

 

Q) What's Dermoelectroporation®?

A) Technically, Dermoelectroporation® uses  a pulsed Ionthophoresis (low currents from 1 to 5 mA as the medical devices  rules require) with "electroporation-like" pulses waveforms shape.
Ultrapeel® Transderm® Meso System uses only the waveform SHAPE of electroporation techniques and neither current peak values, pulses durations nor any other electrical parameters that might be affecting the patients in anyway.

Clinically, Dermoelectroporation® allows the skin's water based  "channels" to open up so that ionic dug solutions can penetrate deep due to particular continuous reversed polarity  electrical pulses. These pulses increase the skin permeability and allow transdermal delivery of drugs. Due to this, either micro-molecules (up to 15,000dalton) and macro-molecules (greater than to 15,000dalton) are safely delivered into the body without either modification of the ionic drug solutions pH and Electrolysis effect of the ionic solution itself.

 

Q) Is Ultrapeel® Transderm® Meso System like a Ionthophoresis machine as the one already on the market?

A) No at all. Ultrapeel® Transderm® Meso System is the newest alternative to injections so that it is completely different from  traditional  Ionthophoresis systems due to its specific pulses waveform and delivery methods. As a matter of fact there is no separate return electrode.
Ultrapeel® Transderm® Meso System instead is equal to a syringe that is capable to deliver either small molecules AND huge molecules.

Traditional Ionthophoresis devices and ultrasounds cannot for example deliver huge molecules such as Hyaluronic Acid,  Eparine etc... 

 

Q) Is Dermoelectroporation® equal to Electroporation?

A) Not at all. Dermoelectroporation®  uses only the waveform SHAPE of electroporation techniques and neither current peak values, pulses durations nor any other electrical parameters that might be affecting the patients in anyway.

 

 

Medical practice FAQs

Q) For what kind of applications can I use the Ultrapeel®Transderm® Meso System?

A)Doctors using Ultrapeel® Transderm® with various applications such as collagen and hyaluronic acid transdermal delivery treatments, pre-laser treatments (anesthetic) for both hair removal and resurfacing. Some others are using Ultrapeel® Transderm® Meso System with cancer drugs or steroid delivery.  Some others are using Ultrapeel® Transderm® Meso System for mesotherapy procedures, cellulite , body sculpting with excellent results.

 

Q) How large a molecular size can you get in via Ionthophoresis?  Growth factors?  Collagen?  Maybe you have a list of materials that are known to be  transported effectively.  

A) Macromolecules (more than 15Kdalton in size to thousand of Kdalton). Doctors deliver Hyaluronic acid, Collagen, Heparin,  Elastine, precursors, amino acids, Vitamins...etc.

 

Q) Does Ultrapeel®Transderm®Meso System  require a pre-charged ionic material?  How about materials that are not ionic?  Do you use a carrier to deliver products, or do you provide them right at the tip without any carrier solution.

A) Ultrapeel®  Transderm® Meso System does not need any pre-charged compound nor carrier to do the job. Non ionic drug solutions are not indicated to be used with Ultrapeel®  Transderm® Meso System.  The system itself delivers the ionic drug solution (water based) from the probe to the patient in a timely manner through a Precision Liquid dispenser (PLD).

 

Q) Is Ultrapeel®Transderm®Meso System Meso System contraindicated for patients with a cardiac pacemaker or defibrillator?

A) According to FDA guidelines, the use of any electrotherapy device with a demand type pacemaker or defibrillator is contraindicated.

 

 Q) Can Ultrapeel®Transderm®Meso System safely be used with a pregnant patient? 

A) The safety of any Ionthophoresis with this patient population has not been established in the literature to date. So the use in these particular conditions is not encouraged.

 

Q) Are there any safety concerns about using a  Ultrapeel®Transderm® Meso System device around machinery or with other implantable medical devices?

A) Some machinery or implantable medical devices may interfere with the operation of Ultrapeel® Transderm® Meso System device.  Examples include equipment that generates high frequency or high energy electromagnetic radiation, patient monitoring equipment, and external defibrillators.

Please refer to Ultrapeel® Transderm® Meso Systemo operating manual for a complete list of contraindications, warnings and precautions.

 

Q) Might Ultrapeel®Transderm® Meso System cause irritations or allergies ?

 A) From experience to date, Ultrapeel® Transderm® Meso System as a methodology does not cause any allergy or irritation . What may cause allergies or irritations are the ionic drug solutions delivered into the skin that are not either part of the machine itself nor belonging to the machine. The only limitation is the eye area. Mattioli Engineering strongly recommends not to go over the eye area in order to avoid possible problems with the retina (not exactly known at this time).

 

Q) Might Ultrapeel®Transderm®Meso System cause red areas on the skin?

A)During normal use, little areas of redness may appear and disappear in a few minutes. Mattioli Engineering suggests not to exert pressure while using the machine to avoid redness on the face particularly.

 

 

TRANSDERM® device FAQs

Q) How deep can we deliver ionic drug solutions?

A) Ultrapeel® Transderm® Meso System is recognized to be able to deliver transdermally until muscle membranes.

 

Q) Does Ultrapeel®Transderm® Meso System  need any carrier product to be effective?

A) No, Ultrapeel® Transderm® Meso System does not need any carrier  to be effective. Due to the Dermoelectroporation technology we just need the ionic drug solution to deliver and that's it.

 

Q) What Ultrapeel®Transderm® Meso System is not?

A) An ultrasound device

An aesthetic-purpose unit

A cosmetic device

A multi-device unit

A massager

A microcurrent device

 

Q) For what kind of applications can I use Ultrapeel®Transderm® Meso System?

A) Worldwide doctors using Ultrapeel® Transderm® Meso System are successfully dealing with various applications such as Collagen and Hyaluronic acid transdermal delivery treatments, pre-laser treatments (anesthetic) for both hair removal and resurfacing; some others are using  Ultrapeel® Transderm® Meso System  with  cancer drugs or steroids delivery; some others are using Ultrapeel® Transderm® Meso System  for mesotherapy procedures, body sculpting, cellulite but all with outstanding.

 
 
 
MATTIOLI ENGINEERING @contact